Nature

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Single-cell mRNA sequencing of peripheral blood mononuclear cells before and 28 days after the first inoculation revealed consistent alterations in gene expression of many different immune cell types, CD8+ T cells reduction and classic monocyte contents increase. Additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.